An umbrella trial design, also known as a basket trial or platform trial, is a type of clinical trial design that allows for the evaluation of multiple treatments or interventions simultaneously. It involves enrolling patients with different types of diseases or conditions that have a common biomarker or molecular profile.
In an umbrella trial, patients are grouped based on the presence of a specific molecular alteration or biomarker, rather than by their disease diagnosis. Each patient group receives a different treatment or intervention that specifically targets the identified molecular alteration or biomarker.
The advantage of an umbrella trial is that it allows for more efficient evaluation of targeted therapies within specific patient populations, as well as the opportunity to identify potential efficacy across different disease types. This design can help to personalize treatment approaches and potentially lead to more effective and precise treatments for patients with specific molecular alterations or biomarkers, regardless of their specific disease diagnosis.
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